Confusion is nice, but full confirm into combo is nicer is think? The purpose of most “confusion/frustration” setups is to condition someone into a suboptimal response, but those should be (I think anyway) smaller, more compact sequences. You want the entire sequence to be short so that you maximize the punishment while minimizing the time the opponent has to respond with something you won’t like (like a DP).
A good example is something like Hologram pestering you with Thunder’s LK buttons on wakeup. It’s something like cr.LK->LK->LK->cmd grab. It’s a relatively fast sequence, punishes jumping, and is really effective for the tick (after eating the third button you’ll tend to finally just block). On the occasions where he mixes it up and goes for ankle slicer to end it instead, there’s a confirm into combo waiting at the end of it if you get hit.
Confusion/frustration setups are fine. Just want to make sure there’s some payoff at the end of it. Be building toward some specific end - frustration just for frustration’s sake isn’t terribly useful against an opponent who doesn’t tilt easily.